C4a Gene Summary [Mouse]
Predicted to enable carbohydrate binding activity and complement component C1q complex binding activity. Acts upstream of or within complement activation. Located in extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement deficiency (multiple); and renal cell carcinoma. Orthologous to human C4A (complement C4A (Chido/Rodgers blood group)) and C4B (complement C4B (Chido/Rodgers blood group)). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | C4a |
| Official Name | complement component 4A (Rodgers blood group) [Source:MGI Symbol;Acc:MGI:98320] |
| Ensembl ID | ENSMUSG00000015451 |
| Bio databases IDs | |
| Aliases | complement component 4A (Rodgers blood group) |
| Synonyms | C4, C4-1, C4-2, C4a, C4b, C4l, complement C4A, complement C4A (Rodgers blood group), complement C4B, complement C4B (Chido blood group), LOC100909666, LOC102549354, LOC103689965, Slp, SlpA, Slp-w7, Ss |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse C4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- Alpha-2-macroglobulin bait region domain
- ISOPREN_C2_like
- binding protein
- A-macroglobulin TED domain
- A-macroglobulin receptor binding domain
- protein binding
- carbohydrate binding
- ANATO
- Alpha-2-macroglobulin family
- Macroglobulin domain MG3
- MG2 domain
Pathways
Biological processes and signaling networks where the C4a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphadenopathy
- polycystic kidney disease
- purkinje cell degeneration
- splenomegaly
- rheumatoid arthritis
- Alzheimer disease
- bullous pemphigoid
- glomerulonephritis
- peritonitis
- cerebral malaria
role in cell
- number
- activation
- apoptosis
- quantity
- innate immune response
- density
- cellular infiltration by
- accumulation
- engulfment
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- synapse
- perikaryon
- axons
- dendrites