Hmg20b Gene Summary [Mouse]
Predicted to enable four-way junction DNA binding activity. Acts upstream of or within negative regulation of protein sumoylation; positive regulation of neuron differentiation; and skeletal muscle cell differentiation. Predicted to be located in condensed nuclear chromosome and nuclear body. Predicted to be part of BRCA2-BRAF35 complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; foregut; and genitourinary system. Orthologous to human HMG20B (high mobility group 20B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmg20b |
| Official Name | high mobility group 20B [Source:MGI Symbol;Acc:MGI:1341190] |
| Ensembl ID | ENSMUSG00000020232 |
| Bio databases IDs | |
| Aliases | high mobility group 20B |
| Synonyms | BRAF25, BRAF35, high mobility group 20 B, HMGX2, HMGXB2, PP7706, pp8857, SMARCE1r, SOXL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hmg20b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- HMG-box domain
- DNA secondary structure binding
- high mobility group
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromosome
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hmg20b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle cell differentiation
- protein sumoylation
- regulation of gene expression
- positive regulation of neuron differentiation
- negative regulation of protein sumoylation
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding