Cxcl3 Gene Summary [Mouse]

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. [provided by RefSeq, May 2013]

Details

Type
Protein Coding
Official Symbol
Cxcl3
Official Name
chemokine (C-X-C motif) ligand 3 [Source:MGI Symbol;Acc:MGI:3037818]
Ensembl ID
ENSMUSG00000029379
Bio databases IDs NCBI: 330122 Ensembl: ENSMUSG00000029379
Aliases chemokine (C-X-C motif) ligand 3
Synonyms Cinc-2, C-X-C motif chemokine ligand 3, Dcip1, Gm1960
Species
Mouse, Mus musculus
OrthologiesRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cxcl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • chemokine
  • Small cytokines (intecrine/chemokine), interleukin-8 like
  • protein binding
  • cytokine

Pathways

Biological processes and signaling networks where the Cxcl3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • multiorgan inflammation
  • pancreatic ductal adenocarcinoma
  • pancreatic epithelial cancer
  • ductal pancreatic cancer
  • age-related hearing loss
  • experimental autoimmune encephalomyelitis
  • familial amyloid polyneuropathy type I
regulated by
role in cell
  • phosphorylation in
  • expression in
  • chemotaxis
  • number
  • elevation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.