Zbp1 Gene Summary [Mouse]
Enables double-stranded RNA binding activity and left-handed Z-DNA binding activity. Involved in several processes, including defense response to other organism; positive regulation of defense response; and positive regulation of programmed cell death. Acts upstream of or within positive regulation of type I interferon-mediated signaling pathway. Located in cytoplasm and nucleus. Is expressed in eye and heart. Orthologous to human ZBP1 (Z-DNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zbp1 |
| Official Name | Z-DNA binding protein 1 [Source:MGI Symbol;Acc:MGI:1927449] |
| Ensembl ID | ENSMUSG00000027514 |
| Bio databases IDs | |
| Aliases | Z-DNA binding protein 1 |
| Synonyms | 2010010H03Rik, C20orf183, DAI, DLM-1, mZaDLM, Z-DNA binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- left-handed Z-DNA binding
- RIP homotypic interaction motif
- double-stranded RNA binding
- protein binding
- identical protein binding
- DNA binding
- RNA binding
- Adenosine deaminase z-alpha domain
Pathways
Biological processes and signaling networks where the Zbp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- diabetic nephropathy
- Huntington disease
- dermatitis
- inflammatory bowel disease
- experimental systemic lupus erythematosus
- schizophrenia
- ulcerative colitis
- insulin-dependent diabetes mellitus
- Crohn disease
role in cell
- cell death
- proliferation
- apoptosis
- binding in
- expression in
- phosphorylation in
- molecular cleavage in
- activation in
- necroptosis
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- granules
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- activation of innate immune response
- regulation of interleukin-1-mediated signaling pathway
- positive regulation of inflammatory response
- positive regulation of type I interferon-mediated signaling pathway
- apoptotic process
- positive regulation of apoptotic process
- pyroptosis
- defense response to virus
- regulation of inflammatory response
- defense response to fungus
- positive regulation of necroptosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- double-stranded RNA binding
- double-stranded RNA adenosine deaminase activity
- left-handed Z-DNA binding