Cebpd Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including fat cell differentiation; positive regulation of osteoblast differentiation; and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; early embryo; genitourinary system; integumental system; and lung. Orthologous to human CEBPD (CCAAT enhancer binding protein delta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cebpd |
| Official Name | CCAAT/enhancer binding protein (C/EBP), delta [Source:MGI Symbol;Acc:MGI:103573] |
| Ensembl ID | ENSMUSG00000071637 |
| Bio databases IDs | |
| Aliases | CCAAT/enhancer binding protein (C/EBP), delta |
| Synonyms | CCAAT enhancer binding protein delta, CCAAT/enhancer binding protein delta, CCAAT enhancer binding protein δ, CCAAT/enhancer-binding protein-δ, C/EBPd, C/EBP-delta, C/EBP-δ, Cebp δ, CELF, C/EPB δ, CRP3, NF-IL6-beta, NF-IL6-β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cebpd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- dimerization domain
- DNA binding domain
- nucleic acid binding
- transcription activation domain
- Basic region leucine zipper
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- bZIP
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Cebpd gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- breast cancer
- neoplasia
- primary myelofibrosis
- plasma cell neoplasm
- Alzheimer disease
- tumorigenesis
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- psoriasis
- organismal death
role in cell
- apoptosis
- cell viability
- production in
- expression in
- activation in
- phosphorylation in
- proliferation
- invasion
- induction in
- acidification in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nuclear foci
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cebpd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear development
- negative regulation of transcription, DNA-dependent
- regulation of cell differentiation
- transcription from RNA polymerase II promoter
- fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- hemopoietic progenitor cell differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity