Fry Gene Summary [Mouse]
Enables enzyme inhibitor activity. Involved in negative regulation of tubulin deacetylation. Predicted to be located in centrosome; cytoplasm; and spindle pole. Predicted to be active in cell cortex and site of polarized growth. Is expressed in several structures, including genitourinary system; nervous system; respiratory system cartilage; sensory organ; and skeleton. Orthologous to human FRY (FRY microtubule binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fry |
| Official Name | FRY microtubule binding protein [Source:MGI Symbol;Acc:MGI:2443895] |
| Ensembl ID | ENSMUSG00000056602 |
| Bio databases IDs | |
| Aliases | FRY microtubule binding protein |
| Synonyms | 13CDNA73, 214K23.2, 9330186A19RIK, bA207N4.2, bA37E23.1, C13orf14, CG003, D930046M03, FRY microtubule binding protein, mKIAA4143, RGD1307034 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fry often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cell morphogenesis N-terminal
- Cell morphogenesis C-terminal
- enzyme inhibitor activity
- Furry protein C-terminal
- Cell morphogenesis central region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- schizophrenia
- metastatic colorectal cancer
- coronary artery disease
- COVID-19
- peripheral arterial disease
- autosomal recessive nonsyndromic mental retardation
- lung squamous cell carcinoma
- squamous cell lung cancer
- cleft lip
role in cell
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fry gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- cell morphogenesis
Cellular Component
Where in the cell the gene product is active
- centrosome
- site of polarized growth
- cell cortex
- spindle pole
Molecular Function
What the gene product does at the molecular level
- enzyme inhibitor activity