Phf14 Gene Summary [Mouse]
Predicted to enable histone binding activity; histone reader activity; and zinc ion binding activity. Involved in germinal center B cell differentiation. Acts upstream of or within several processes, including lung alveolus development; negative regulation of mesenchymal cell proliferation involved in lung development; and negative regulation of platelet-derived growth factor receptor-alpha signaling pathway. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; hindlimb phalanx; nervous system; and tooth. Orthologous to human PHF14 (PHD finger protein 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phf14 |
| Official Name | PHD finger protein 14 [Source:MGI Symbol;Acc:MGI:1923539] |
| Ensembl ID | ENSMUSG00000029629 |
| Bio databases IDs | |
| Aliases | PHD finger protein 14 |
| Synonyms | 1110001C23Rik, 4932409F11RIK, 5730446A07RIK, mKIAA0783, PHD finger protein 14, RGD1563764 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phf14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- histone binding
- PHD-like zinc-binding domain
- zinc ion binding
- protein binding activity, bridging
- PHD finger superfamily
- protein binding
- PHD-zinc-finger like domain
- PHD-finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- liver cancer
- epithelial cancer
- epithelial neoplasia
- hepatocellular carcinoma
- renal clear cell adenocarcinoma
- gastric adenocarcinoma
- cutaneous melanoma
- transitional cell bladder cancer
role in cell
- expression in
- proliferation
- migration
- binding in
- differentiation
- colony formation
- invasion by
- DNA methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phf14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- lung alveolus development
- germinal center B cell differentiation
- negative regulation of mesenchymal cell proliferation involved in lung development
- negative regulation of mesenchymal cell proliferation
- negative regulation of cell proliferation
- mesenchymal cell proliferation involved in lung development
- chromatin organization
- mesenchymal cell proliferation
- negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromosome
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- histone binding