Usp12 Gene Summary [Mouse]
Enables deubiquitinase activity. Acts upstream of or within protein deubiquitination. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol and nucleus. Is expressed in central nervous system; gonad; metanephros; and retina layer. Orthologous to human USP12 (ubiquitin specific peptidase 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp12 |
| Official Name | ubiquitin specific peptidase 12 [Source:MGI Symbol;Acc:MGI:1270128] |
| Ensembl ID | ENSMUSG00000029640 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 12 |
| Synonyms | LOC684318, UBH1, ubiquitin specific peptidase 12, USP12L1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine endopeptidase
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
- Peptidase_C19
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Usp12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- non-small cell lung cancer
- neoplasia
- breast cancer
- KRAS G12D mutation positive lung cancer
- plasma cell myeloma
role in cell
- proliferation
- apoptosis
- ubiquitination in
- activation in
- stabilization in
- colony formation
- autophagy in
- destabilization in
- deubiquitination in
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- metal ion binding
- cysteine-type endopeptidase activity