Sh3pxd2a Gene Summary [Mouse]
Enables phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and protease binding activity. Involved in reactive oxygen species metabolic process. Acts upstream of or within in utero embryonic development. Located in cytoplasm and podosome. Is expressed in several structures, including brain; clavicle; liver; skeletal muscle; and spleen. Orthologous to human SH3PXD2A (SH3 and PX domains 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh3pxd2a |
| Official Name | SH3 and PX domains 2A [Source:MGI Symbol;Acc:MGI:1298393] |
| Ensembl ID | ENSMUSG00000053617 |
| Bio databases IDs | |
| Aliases | SH3 and PX domains 2A |
| Synonyms | 2310014D11RIK, AI413738, C230050L11, EG329070, FISH, Gm5098, SH3 and PX domains 2A, SH3MD1, TKS5, TSK5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sh3pxd2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protease binding
- phosphatidylinositol-4,5-bisphosphate binding
- Bacterial SH3 domain
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- phosphatidylinositol binding
- PX domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- idiopathic pulmonary fibrosis
- atrial fibrillation
- organismal death
- rosacea
- COVID-19
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- asthma
- ischemic stroke
- arrhythmia
role in cell
- differentiation
- apoptosis
- activation in
- phosphorylation in
- expression in
- survival
- cell death
- generation in
- proliferation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- circumferential podosome
- invadopodia
- Extracellular Space
- podosomes
- Plasma Membrane
- cytosol
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sh3pxd2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- superoxide metabolic process
- osteoclast fusion
- in utero embryonic development
- superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- anchoring junction
- cytoplasm
- cytosol
- cell projection
- podosome
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- phosphatidylinositol-5-phosphate binding
- superoxide-generating NADPH oxidase activator activity
- protease binding
- phosphatidylinositol-3-phosphate binding
- phosphatidylinositol-3,4-bisphosphate binding