Sh3pxd2a Gene Summary [Mouse]
Enables phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and protease binding activity. Involved in reactive oxygen species metabolic process. Acts upstream of or within in utero embryonic development. Located in cytoplasm and podosome. Is expressed in several structures, including brain; clavicle; liver; skeletal muscle; and spleen. Orthologous to human SH3PXD2A (SH3 and PX domains 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh3pxd2a |
| Official Name | SH3 and PX domains 2A [Source:MGI Symbol;Acc:MGI:1298393] |
| Ensembl ID | ENSMUSG00000053617 |
| Bio databases IDs | |
| Aliases | SH3 and PX domains 2A |
| Synonyms | 2310014D11RIK, AI413738, C230050L11, EG329070, FISH, Gm5098, SH3 and PX domains 2A, SH3MD1, TKS5, TSK5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sh3pxd2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protease binding
- phosphatidylinositol-4,5-bisphosphate binding
- Bacterial SH3 domain
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- phosphatidylinositol binding
- PX domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- idiopathic pulmonary fibrosis
- atrial fibrillation
- organismal death
- rosacea
- COVID-19
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- asthma
- ischemic stroke
- arrhythmia
phenotypes
- decreased circulating insulin level
- decreased compact bone thickness
- increased circulating alkaline phosphatase level
- preweaning lethality complete penetrance
- short femur
- abnormal Mullerian duct morphology
- abnormal Mullerian duct topology
- abnormal Wolffian duct connection
- abnormal adenohypophysis morphology
- abnormal aortic valve cusp morphology
- abnormal artery morphology
- abnormal atrioventricular cushion morphology
- abnormal basilar artery morphology
- abnormal basioccipital bone morphology
- abnormal brain morphology
- abnormal cervical rib
- abnormal circulating alkaline phosphatase level
- abnormal digastric muscle connection
- abnormal ductus venosus valve topology
- abnormal eye muscle morphology
- abnormal eye muscle topology
- abnormal forebrain morphology
- abnormal heart position or orientation
- abnormal hepatic vein morphology
- abnormal hyoid bone body morphology
- abnormal hypoglossal nerve topology
- abnormal inferior vena cava morphology
- abnormal infrahyoid muscle connection
- abnormal interatrial septum morphology
- abnormal kidney morphology
- abnormal larynx morphology
- abnormal left vena cava superior connection
- abnormal liver morphology
- abnormal liver vasculature morphology
- abnormal lung position or orientation
- abnormal lymphatic vessel morphology
- abnormal muscle morphology
- abnormal nasal cavity morphology
- abnormal nasal septum morphology
- abnormal occipital bone morphology
- abnormal olfactory bulb position
- abnormal optic cup morphology
- abnormal oral cavity morphology
- abnormal ovary tissue architecture
- abnormal pectinate muscle morphology
- abnormal pineal gland morphology
- abnormal pulmonary valve cusp morphology
- abnormal right lung morphology
- abnormal semilunar valve morphology
- abnormal stapedial artery topology
- abnormal testis morphology
- abnormal thymus topology
- abnormal vascular plexus formation
- abnormal vertebral arch morphology
- abnormal vertebral artery origin
- abnormal vertebral body morphology
- abnormal vitelline vein topology
- abnormal vomeronasal organ morphology
- abnormally deep median sulcus of tongue
- absent canalicular internal carotid artery segment
- absent celiac artery
- absent connection between subcutaneous lymph vessels and lymph sac
- absent ductus venosus valve
- absent gastric milk in neonates
- absent hypoglossal canal
- absent hypoglossal nerve
- absent parasellar internal carotid artery
- absent segment of posterior cerebral artery
- absent stapedial artery
- absent styloid process
- absent sublingual gland
- atrial septal defect
- basisphenoid bone foramen
- bicuspid aortic valve
- bicuspid pulmonary valve
- bifid ureter
- blood in lymph vessels
- cerebral arteriovenous malformation
- cleft secondary palate
- diaphragmatic hernia
- dilated bile duct
- double inlet heart left ventricle
- double outlet right ventricle
- double outlet right ventricle with atrioventricular septal defect
- double ureter
- dual inferior vena cava
- embryo cyst
- enlarged fourth ventricle
- enlarged liver sinusoidal spaces
- enlarged third ventricle
- fetal growth retardation
- fragmented Meckel's cartilage
- fused dorsal root ganglion
- fusion of atlas and occipital bones
- fusion of axis and occipital bones
- fusion of vertebral arches
- herniated liver
- heterochrony
- inverse situs of great intrathoracic arteries
- liver hypoplasia
- muscular ventricular septal defect
- neonatal lethality incomplete penetrance
- ostium primum atrial septal defect
- pelvic kidney
- perimembraneous ventricular septal defect
- perinatal lethality incomplete penetrance
- persistent right 6th pharyngeal arch artery
- persistent right dorsal aorta
- persistent trigeminal artery
- persistent truncus arteriosis
- premature death
- preweaning lethality incomplete penetrance
- reduced sympathetic cervical ganglion size
- retropharyngeal edema
- retropleural edema
- short snout
- short tongue
- small prevertebral sympathetic ganglia
- small superior cervical ganglion
- small thyroid gland
- split xiphoid process
- subcutaneous edema
- symmetric azygos veins
- thoracoschisis
- transposition of great arteries
- urinary bladder hypoplasia
role in cell
- differentiation
- apoptosis
- activation in
- phosphorylation in
- expression in
- survival
- cell death
- generation in
- proliferation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- circumferential podosome
- invadopodia
- Extracellular Space
- podosomes
- Plasma Membrane
- cytosol
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sh3pxd2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- superoxide metabolic process
- osteoclast fusion
- in utero embryonic development
- superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- anchoring junction
- cytoplasm
- cytosol
- cell projection
- podosome
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- phosphatidylinositol-5-phosphate binding
- superoxide-generating NADPH oxidase activator activity
- protease binding
- phosphatidylinositol-3-phosphate binding
- phosphatidylinositol-3,4-bisphosphate binding