Cdk5rap2 Gene Summary [Mouse]
Predicted to enable several functions, including calmodulin binding activity; protein kinase binding activity; and tubulin binding activity. Involved in several processes, including establishment of mitotic spindle orientation; negative regulation of centriole replication; and nervous system development. Located in centrosome and mitotic spindle pole. Is expressed in central nervous system and retina. Used to study microcephaly. Human ortholog(s) of this gene implicated in Seckel syndrome; microcephaly; and primary autosomal recessive microcephaly 3. Orthologous to human CDK5RAP2 (CDK5 regulatory subunit associated protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Cdk5rap2 |
| Official Name | CDK5 regulatory subunit associated protein 2 [Source:MGI Symbol;Acc:MGI:2384875] |
| Ensembl ID | ENSMUSG00000039298 |
| Bio databases IDs | |
| Aliases | CDK5 regulatory subunit associated protein 2 |
| Synonyms | 2900018K03Rik, AI449032, an, C48, CDK5 regulatory subunit associated protein 2, Cep215, LOC286919, MCPH3, mKIAA1633 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdk5rap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Autophagy protein 16 (ATG16)
- protein kinase binding
- calmodulin binding
- Centrosomin N-terminal motif 1
- nucleic acid binding
- helix-rich Mycoplasma protein
- protein binding
- sequence-specific DNA binding
- gamma-tubulin binding
- microtubule binding
- binding protein
- tubulin binding
- double-stranded DNA binding
- Septation ring formation regulator, EzrA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- autosomal recessive primary microcephaly type 3
- hereditary disorder
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- urethral syndrome
- rheumatoid arthritis
- septic shock
- leukopenia
- myeloid/lymphoid neoplasm with eosinophilia
role in cell
- differentiation
- migration
- formation
- number
- organization
- nucleation
- sphere formation
- segregation
- replication
- orientation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- perinuclear region
- basal bodies
- centrosome
- Golgi Apparatus
- microtubules
- cytosol
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdk5rap2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome cycle
- centriole replication
- regulation of mitotic cell cycle spindle assembly checkpoint
- negative regulation of centriole replication
- negative regulation of neuron differentiation
- chromosome segregation
- neurogenesis
- microtubule cytoskeleton organization
- brain development
- regulation of neuron differentiation
- establishment of mitotic spindle orientation
- microtubule bundle formation
- positive regulation of transcription, DNA-dependent
- microtubule organizing center organization
- positive regulation of microtubule polymerization
Cellular Component
Where in the cell the gene product is active
- microtubule plus end
- spindle pole
- gamma-tubulin large complex
- Golgi apparatus
- microtubule
- pericentriolar material
- centrosome
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoskeleton
- cytoplasm
- cytosol
- cell junction
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- tubulin binding
- calmodulin binding
- protein binding
- transcription regulatory region sequence-specific DNA binding
- gamma-tubulin binding
- microtubule binding