Plxna4 Gene Summary [Mouse]
Enables semaphorin receptor activity. Involved in several processes, including maintenance of synapse structure; nervous system development; and semaphorin-plexin signaling pathway. Acts upstream of or within nervous system development; regulation of axon extension involved in axon guidance; and regulation of negative chemotaxis. Is active in cerebellar climbing fiber to Purkinje cell synapse. Is expressed in several structures, including alimentary system; nervous system; and sensory organ. Orthologous to human PLXNA4 (plexin A4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plxna4 |
| Official Name | plexin A4 [Source:MGI Symbol;Acc:MGI:2179061] |
| Ensembl ID | ENSMUSG00000029765 |
| Bio databases IDs | |
| Aliases | plexin A4 |
| Synonyms | 9330117B14, FAYV2820, mKIAA1550, PLEXA4, plexin A4, Plxa4, PLXNA4A, PLXNA4B, PRO34003 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plxna4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Plexin repeat
- IPT
- Plexin cytoplasmic RasGAP domain
- protein binding
- TIG domain
- Ras GTPase Activating Domain
- semaphorin domain
- Plexin cytoplasmic RhoGTPase-binding domain
- Ubl1_cv_Nsp3_N-like
- TIG domain found in plexin
- IPT/TIG domain
- semaphorin receptor
- Sema domain
- transmembrane receptor
- The Sema domain, a protein interacting module, of semaphorins and plexins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- spontaneous abortion
- colorectal cancer
- diabetic nephropathy
- brain concussion
- age-related hearing loss
- intracranial hemorrhage
- Down syndrome
- bipolar disorder
- gestational diabetes mellitus
role in cell
- cell death
- apoptosis
- proliferation
- expression in
- phosphorylation in
- stimulation
- growth
- differentiation
- morphogenesis
- sum total
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- neurites
- synaptosomes
- synapse
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plxna4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- motor axon guidance
- trigeminal nerve structural organization
- glossopharyngeal nerve morphogenesis
- negative regulation of cell adhesion
- vagus nerve morphogenesis
- facial nerve structural organization
- embryonic heart tube development
- chemorepulsion of branchiomotor axon
- anterior commissure morphogenesis
- postganglionic parasympathetic nervous system development
- branchiomotor neuron axon guidance
- sympathetic nervous system development
- positive regulation of axonogenesis
- regulation of axon extension involved in axon guidance
- regulation of GTPase activity
- regulation of negative chemotaxis
- regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- semaphorin receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- semaphorin receptor activity