Igfbp1 Gene Summary [Mouse]
Enables insulin-like growth factor binding activity. Acts upstream of or within response to insulin. Located in extracellular space. Is expressed in several structures, including early embryo; jaw; liver; mandible primordium; and secondary oocyte. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igfbp1 |
| Official Name | insulin-like growth factor binding protein 1 [Source:MGI Symbol;Acc:MGI:96436] |
| Ensembl ID | ENSMUSG00000020429 |
| Bio databases IDs | |
| Aliases | insulin-like growth factor binding protein 1 |
| Synonyms | AFBP, hIGFBP-1, IBP1, IGFBA, IGF-BP25, IGFBP-RP1, insulin-like growth factor binding protein 1, PP12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Igfbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TY
- RGD motif
- insulin-like growth factor binding
- protein binding
- receptor binding
- Insulin-like growth factor binding protein
Pathways
Biological processes and signaling networks where the Igfbp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- lung squamous cell carcinoma
- squamous cell lung cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- metabolic disorder
- hepatic steatosis
- cholangiocarcinoma
- cholangiocarcinoma cancer
role in cell
- expression in
- proliferation
- apoptosis
- phosphorylation in
- activation in
- migration
- quantity
- growth
- adhesion
- area
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi Apparatus
- endoplasmic reticulum lumen
- neuromuscular junctions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Igfbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- positive regulation of cell growth
- insulin receptor signaling pathway
- signal transduction
- response to organic cyclic compound
- regulation of insulin-like growth factor receptor signaling pathway
- tissue regeneration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- Golgi apparatus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding
- insulin-like growth factor binding
- insulin-like growth factor I binding
- insulin-like growth factor II binding