MTPN Gene Summary [Human]
The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MTPN |
| Official Name | myotrophin [Source:HGNC Symbol;Acc:HGNC:15667] |
| Ensembl ID | ENSG00000105887 |
| Bio databases IDs | |
| Aliases | myotrophin, granule cell differentiation protein |
| Synonyms | 5033418D15Rik, Beta-dg, GCDP, MYOTROPHIN, Scid complementing gene 2, V-1, β-dg |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MTPN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- protein binding
- sequence-specific DNA binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- differentiation
- growth
- size
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell surface
- cytosol
- growth cone
- axons
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MTPN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cerebellar granule cell differentiation
- neuron differentiation
- regulation of cell size
- catecholamine metabolic process
- positive regulation of NF-kappaB transcription factor activity
- skeletal muscle tissue regeneration
- regulation of translation
- positive regulation of protein metabolic process
- positive regulation of cell growth
- cellular response to mechanical stimulus
- striated muscle cell differentiation
- regulation of barbed-end actin filament capping
- positive regulation of cardiac muscle hypertrophy
- positive regulation of macromolecule biosynthetic process
- regulation of striated muscle tissue development
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- F-actin capping protein complex
- axon
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding