Lrig1 Gene Summary [Mouse]
Acts upstream of or within several processes, including innervation; otolith morphogenesis; and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and sensory organ. Orthologous to human LRIG1 (leucine rich repeats and immunoglobulin like domains 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Lrig1 |
| Official Name | leucine-rich repeats and immunoglobulin-like domains 1 [Source:MGI Symbol;Acc:MGI:107935] |
| Ensembl ID | ENSMUSG00000030029 |
| Bio databases IDs | |
| Aliases | leucine-rich repeats and immunoglobulin-like domains 1 |
| Synonyms | D6Bwg0781e, DKFZp586O1624, Img, leucine-rich repeats and immunoglobulin-like domains 1, LIG-1, Lrig |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrig1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- immunoglobulin domain
- Immunoglobulin I-set domain
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
- leucine-rich repeat
- CD19_double_Ig
- Immunoglobulin like
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- chronic lymphocytic leukemia
- psoriasis
- parakeratosis
- preeclampsia
- atrial fibrillation
- tumorigenesis
- glioma formation
- cleft palate with cleft lip
- chronic bronchitis
role in cell
- expression in
- phosphorylation in
- apoptosis
- proliferation
- cell death
- differentiation
- growth
- transformation
- cell cycle progression
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- cell periphery
- perinuclear region
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrig1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- innervation
- otolith morphogenesis
- hair cycle process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding