Lag3 Gene Summary [Mouse]
Enables MHC class II protein binding activity and transmembrane signaling receptor activity. Involved in several processes, including cell surface receptor signaling pathway; negative regulation of regulatory T cell differentiation; and plasmacytoid dendritic cell activation. Acts upstream of or within negative regulation of interleukin-2 production and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lag3 |
| Official Name | lymphocyte-activation gene 3 [Source:MGI Symbol;Acc:MGI:106588] |
| Ensembl ID | ENSMUSG00000030124 |
| Bio databases IDs | |
| Aliases | lymphocyte-activation gene 3 |
| Synonyms | CD223, Ly66, lymphocyte activating 3, Lymphocyte-Activation Gene 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lag3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MHC class II protein binding
- CD19_double_Ig
- Glu-Pro repeat domain
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- intracellular domain
- antigen binding
- cytosolic tail domain
- protein binding
- transmembrane receptor
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- advanced non-squamous non-small cell lung cancer
- metastatic non-small cell lung cancer
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- diabetes mellitus
- lymphoma
- cancer
- epithelial cancer
- epithelial neoplasia
- cutaneous melanoma
role in cell
- phosphorylation in
- proliferation
- apoptosis
- cell death
- formation
- production in
- activation
- binding
- differentiation
- inhibition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- lysosome
- plasma membrane extracellular face
- late endosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lag3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-2 production
- negative regulation of regulatory T cell differentiation
- plasmacytoid dendritic cell activation
- T cell activation
- adaptive immune response
- cell surface receptor signaling pathway
- natural killer cell mediated cytotoxicity
- positive regulation of natural killer cell mediated cytotoxicity
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- antigen binding
- MHC class II protein binding