Pik3c2g Gene Summary [Mouse]
Enables 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in chemotaxis and phosphatidylinositol-3-phosphate biosynthetic process. Located in membrane. Is expressed in alimentary system; central nervous system; liver; and retina. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PIK3C2G (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pik3c2g |
| Official Name | phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [Source:MGI Symbol;Acc:MGI:1203730] |
| Ensembl ID | ENSMUSG00000030228 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma |
| Synonyms | C80387, LRRG00132, phosphatidylinositol 3 kinase, class 2 γ, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 γ, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 γ, PI3K-C2GAMMA, PI3K-C2-γ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pik3c2g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- phosphatidylinositol 3-kinase
- Phosphoinositide 3-kinase, catalytic domain
- phosphatidylinositol-4-phosphate 3-kinase
- Protein Kinases, catalytic domain
- Phosphatidylinositol 3- and 4-kinase
- The Phox Homology domain, a phosphoinositide binding module
- PI3-kinase family, ras-binding domain
- Protein kinase C conserved region 2 (CalB)
- PX domain
- PI3Ka
- C2 domain
Pathways
Biological processes and signaling networks where the Pik3c2g gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Clathrin-mediated Endocytosis Signaling
- CNTF Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Ephrin A Signaling
- ErbB Signaling
- ErbB4 Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-9 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Mouse Embryonic Stem Cell Pluripotency
- MSP-RON Signaling Pathway
- Neurotrophin/TRK Signaling
- p53 Signaling
- PDGF Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th1 Pathway
- Th2 Pathway
- Thyroid Cancer Signaling
- UVA-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- schizophrenia
- progressive supranuclear palsy
- aldosterone producing adrenocortical adenoma
- adenoma formation
- febrile seizure
- flu
- medulloblastoma SHH subtype
- brain cancer
- glioblastoma cancer
role in cell
- production in
- degradation in
- clustering in
- replication in
- entrance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- cytosol
- nuclear envelope
- clathrin-coated pits
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pik3c2g gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- protein kinase B signaling cascade
- phosphatidylinositol-mediated signaling
- phosphatidylinositol-3-phosphate biosynthetic process
- cell migration
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex
- cytoplasm
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol kinase activity
- ATP binding
- phosphatidylinositol binding
- 1-phosphatidylinositol-4-phosphate 3-kinase activity
- 1-phosphatidylinositol-3-kinase activity