Plcz1 Gene Summary [Mouse]
Enables phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Involved in positive regulation of cytosolic calcium ion concentration involved in egg activation. Acts upstream of or within calcium ion transport and egg activation. Located in nucleolus; nucleoplasm; and pronucleus. Is expressed in several structures, including alimentary system; heart; integumental system; limb; and nervous system. Human ortholog(s) of this gene implicated in spermatogenic failure 17. Orthologous to human PLCZ1 (phospholipase C zeta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plcz1 |
| Official Name | phospholipase C, zeta 1 [Source:MGI Symbol;Acc:MGI:2150308] |
| Ensembl ID | ENSMUSG00000030230 |
| Bio databases IDs | |
| Aliases | phospholipase C, zeta 1 |
| Synonyms | 1700041H07Rik, NYD-SP27, phospholipase C zeta 1, phospholipase C, zeta 1, phospholipase C ζ 1, phospholipase C, ζ 1, PLCzeta, PLC-zeta-1, PLC-ζ-1, SPGF17 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plcz1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphatidylinositol-specific phospholipase C, Y domain
- enzyme
- phospholipase C
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- phosphatidylinositol binding
- EFh_PI-PLC
- phosphoinositide phospholipase C
- Phosphatidylinositol-specific phospholipase C, X domain
- Phospholipase C, catalytic domain (part: domain X)
- Phosphoinositide-specific phospholipase C, efhand-like
- phosphatidylinositol-4,5-bisphosphate binding
- Phospholipase C, catalytic domain (part: domain Y)
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Pathways
Biological processes and signaling networks where the Plcz1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Antioxidant Action of Vitamin C
- Apelin Cardiomyocyte Signaling Pathway
- Cellular Effects of Sildenafil (Viagra)
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endothelin-1 Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Gap Junction Signaling
- Glioblastoma Multiforme Signaling
- Leptin Signaling in Obesity
- Melatonin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Role of NFAT in Cardiac Hypertrophy
- Serotonin Receptor Signaling
- Sphingosine-1-phosphate Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- UVA-Induced MAPK Signaling
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- spermatogenic failure 17
- cryptorchidism
- diabetic nephropathy
regulated by
- phosphtidylinositol 5-phosphate
- DDX25
- phosphatidylinositol 4,5-bisphosphate
- phosphatidylinositol-3-phosphate
regulates
- Ca2+
- CAMK2A
- CAMK2
- phosphatidylinositol 4,5-bisphosphate
role in cell
- activation
- elevation in
- calcium oscillation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- acrosome
- sperm head
- pronucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plcz1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- elevation of cytosolic calcium ion concentration involved in egg activation
- calcium ion transport
- lipid catabolic process
- egg activation
- intracellular signal transduction
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- pronucleus
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- phosphatidylinositol-4,5-bisphosphate binding
- calcium ion binding
- phosphatidylinositol-5-phosphate binding
- phosphatidylinositol-3-phosphate binding