Mtmr14 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity and phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be located in perinuclear region of cytoplasm and ruffle. Is expressed in cerebral cortex and retina. Human ortholog(s) of this gene implicated in centronuclear myopathy 1. Orthologous to human MTMR14 (myotubularin related protein 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtmr14 |
| Official Name | myotubularin related protein 14 [Source:MGI Symbol;Acc:MGI:1916075] |
| Ensembl ID | ENSMUSG00000030269 |
| Bio databases IDs | |
| Aliases | myotubularin related protein 14 |
| Synonyms | 1110061O04Rik, C3orf29, myotubularin related protein 14, RGD1304842 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtmr14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine phosphatase
- phosphatidylinositol-3-phosphatase
- phosphatase
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- fatigue
- teratozoospermia
- asthenozoospermia
- hairpin sperm flagellum
- chronic lymphocytic leukemia
- centronuclear myopathy
- exercise intolerance
- autosomal dominant centronuclear myopathy-1
regulated by
- lipopolysaccharide
- CITED2
role in cell
- apoptosis
- number
- macroautophagy in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- perinuclear region
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtmr14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylinositol biosynthetic process
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- ruffle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- phosphatidylinositol-3-phosphatase activity
- protein binding
- phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity