Atp2b3 Gene Summary [Mouse]
Predicted to enable P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration and PDZ domain binding activity. Predicted to be involved in calcium ion export across plasma membrane and regulation of cytosolic calcium ion concentration. Predicted to be located in parallel fiber. Predicted to be active in several cellular components, including GABA-ergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1. Orthologous to human ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp2b3 |
| Official Name | ATPase, Ca++ transporting, plasma membrane 3 [Source:MGI Symbol;Acc:MGI:1347353] |
| Ensembl ID | ENSMUSG00000031376 |
| Bio databases IDs | |
| Aliases | ATPase, Ca++ transporting, plasma membrane 3 |
| Synonyms | 6430519O13Rik, ATPase, Ca++ transporting, plasma membrane 3, ATPase plasma membrane Ca2+ transporting 3, CFAP39, CLA2, OPCA, PMCA3, SCAX1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp2b3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoglycolate phosphatase, TA0175-type
- Cation transporter/ATPase, N-terminus
- regulatory domain
- sarco/endoplasmic reticulum calcium-translocating P-type ATPase
- heavy metal translocating P-type ATPase
- E1-E2 ATPase
- copper-(or silver)-translocating P-type ATPase
- plasma-membrane calcium-translocating P-type ATPase
- phospholipid-translocating P-type ATPase, flippase
- Na,H/K antiporter P-type ATPase alpha subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Cation transport ATPase (P-type)
- Cation transporting ATPase, C-terminus
- Ca2+-transporting ATPase
- calcium ion transporter
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- calmodulin binding domain
- protein binding
- P-type ATPase of unknown pump specificity (type V)
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- Plasma membrane calcium transporter ATPase C terminal
- PDZ-domain binding
- K+-transporting ATPase, B subunit
- Haloacid Dehalogenase-like Hydrolases
- transporter
Pathways
Biological processes and signaling networks where the Atp2b3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- X-linked spinocerebellar ataxia type 1
- hereditary disorder
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- aldosterone producing adrenocortical adenoma
- hereditary spastic ataxia
- X-linked congenital cerebellar ataxia
- developmental delay and generalized hypotonia and cerebellar ataxia
regulates
- Ca2+
- CYP11B2
- aldosterone
- ion
role in cell
- expression in
- production in
- homeostasis in
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- glutaminergic synapse
- cellular membrane
- Nucleus
- actin bundles
- apical membrane
- presynaptic membrane
- basolateral membrane
- synapse
- cuticular plate
- excitatory synapses
- parallel fiber
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp2b3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
- cytosolic calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- intracellular membrane-bounded organelle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- calmodulin binding
- protein binding
- metal ion binding
- PDZ domain binding
- calcium ion transmembrane transporter activity
- calcium-transporting ATPase activity