Galnt6 Gene Summary [Mouse]
Enables polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via threonine. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Is expressed in exocrine system; paravertebral ganglion; and skeleton. Orthologous to human GALNT6 (polypeptide N-acetylgalactosaminyltransferase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Galnt6 |
| Official Name | polypeptide N-acetylgalactosaminyltransferase 6 [Source:MGI Symbol;Acc:MGI:1891640] |
| Ensembl ID | ENSMUSG00000037280 |
| Bio databases IDs | |
| Aliases | polypeptide N-acetylgalactosaminyltransferase 6 |
| Synonyms | 4632410F13, GALNAC-T6, polypeptide N-acetylgalactosaminyltransferase 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Galnt6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ricin-type beta-trefoil lectin domain
- Glycosyl transferase family 2
- Ricin-type beta-trefoil
- polypeptide N-acetylgalactosaminyltransferase
- N-terminal domain of galactosyltransferase
- enzyme
- protein binding
- ricin B-type lectin domain, beta-trefoil fold
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- colon adenocarcinoma
- colon epithelial cancer
- keratoconus
- insulin-dependent diabetes mellitus
- colorectal adenoma
- colorectal adenoma formation
role in cell
- growth
- expression in
- morphology
- proliferation
- formation by
- stabilization in
- O-glycosylation in
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Galnt6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein O-linked glycosylation
- protein O-linked glycosylation via threonine
- O-glycan processing
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- carbohydrate binding
- polypeptide N-acetylgalactosaminyltransferase activity