Lrrk1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and protein kinase activity. Acts upstream of or within several processes, including bone resorption; osteoclast development; and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in osteosclerotic metaphyseal dysplasia. Orthologous to human LRRK1 (leucine rich repeat kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Lrrk1 |
| Official Name | leucine-rich repeat kinase 1 [Source:MGI Symbol;Acc:MGI:2142227] |
| Ensembl ID | ENSMUSG00000015133 |
| Bio databases IDs | |
| Aliases | leucine-rich repeat kinase 1 |
| Synonyms | AW319595, C230002E15RIK, D130026O16RIK, leucine-rich repeat kinase 1, Lrrk1 predicted, mKIAA1790, OSMD, RIPK6, Roco1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrrk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Roc domain
- Protein kinase (unclassified specificity)
- protein phosphatase 1 regulatory subunit 42
- Protein tyrosine and serine/threonine kinase
- Ankyrin repeats (3 copies)
- Leucine rich repeat
- protein binding
- C-terminal of Roc, COR, domain
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Ras of Complex, Roc, domain of DAPkinase
- COR domain
- Tyrosine kinase, catalytic domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- celiac disease
- osteosclerotic metaphyseal dysplasia
- Crohn disease
- osteopetrosis
- systemic lupus erythematosus
- anti-N-methyl-D-aspartate receptor encephalitis
- osteosclerosis
- Dupuytren contracture
- male pattern hair loss
regulates
- ALP
- L-tyrosine
- EGFR
- peptide
role in cell
- function
- number
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrrk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoclast development
- bone resorption
- positive regulation of canonical Wnt receptor signaling pathway
- protein phosphorylation
- intracellular signal transduction
- positive regulation of peptidyl-tyrosine phosphorylation
- negative regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATP binding
- identical protein binding
- protein binding
- metal ion binding
- protein serine/threonine kinase activity