Lpl

Enables lipoprotein lipase activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of macrophage derived foam cell differentiation; and triglyceride catabolic process. Acts upstream of or within response to bacterium. Located in cell surface and extracellular space. Is active in extracellular region. Is expressed in several structures, including brain; cardiovascular system; limb; lung; and sensory organ. Used to study familial lipoprotein lipase deficiency. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein lipase). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lpl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Lpl gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Lpl gene, providing context for its role in the cell.