Sipa1l3 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Involved in several processes, including epithelial cell morphogenesis; establishment of epithelial cell polarity; and eye development. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in several cellular components, including nucleoplasm; stress fiber; and tricellular tight junction. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in lens; lens anterior epithelium; lens fiber; lens vesicle; and lens vesicle anterior epithelium. Human ortholog(s) of this gene implicated in cataract 45. Orthologous to human SIPA1L3 (signal induced proliferation associated 1 like 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sipa1l3 |
| Official Name | signal-induced proliferation-associated 1 like 3 [Source:MGI Symbol;Acc:MGI:1921456] |
| Ensembl ID | ENSMUSG00000030583 |
| Bio databases IDs | |
| Aliases | signal-induced proliferation-associated 1 like 3 |
| Synonyms | 2610511M17RIK, CTRCT45, SI1L3, signal-induced proliferation-associated 1 like 3, SPAL3, SPAR3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sipa1l3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rap/ran-GAP
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- protein binding
- C-terminal domain of SPAR protein
- PDZ domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- epithelial cancer
- prostate cancer
- hyperuricemia
- COVID-19
- prostatic carcinoma
- cataract type 45
- myocardial infarction
- androgenic alopecia
- Richter syndrome
role in cell
- differentiation
- morphogenesis
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- organelle
- apical compartment
- Plasma Membrane
- Golgi Apparatus
- intercellular junctions
- nucleoplasm
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sipa1l3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- eye development
- cytoskeleton organization
- regulation of small GTPase mediated signal transduction
- epithelial cell morphogenesis
- establishment of epithelial cell polarity
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- apical part of cell
- cytoplasm
- stress fiber
- Golgi apparatus
- plasma membrane
- apical plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity