Lpp Gene Summary [Mouse]
Predicted to enable metal ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be located in cytosol. Predicted to be active in focal adhesion and stress fiber. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and musculoskeletal system. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human LPP (LIM domain containing preferred translocation partner in lipoma). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Lpp |
| Official Name | LIM domain containing preferred translocation partner in lipoma [Source:MGI Symbol;Acc:MGI:2441849] |
| Ensembl ID | ENSMUSG00000033306 |
| Bio databases IDs | |
| Aliases | LIM domain containing preferred translocation partner in lipoma |
| Synonyms | 9430020K16RIK, B130055L10Rik, D630048H16, LIM domain containing preferred translocation partner in lipoma |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lpp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- acute myeloid leukemia
- Hodgkin disease
- squamous cell cancer
- epithelial cancer
- Hodgkin lymphoma
- systemic lupus erythematosus
- autoimmune disease
- Addison disease
- inflammatory bowel disease
regulates
- Vinculin
- Lpp
role in cell
- differentiation
- migration
- cell spreading
- invasion by
- assembly in
- disassembly in
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- focal adhesions
- Plasma Membrane
- cell-cell contacts
- cytosol
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lpp gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- focal adhesion
- stress fiber
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding