NSMCE1 Gene Summary [Human]
Enables protein dimerization activity and ubiquitin protein ligase activity. Involved in positive regulation of response to DNA damage stimulus. Located in nucleoplasm. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NSMCE1 |
| Official Name | NSE1 homolog, SMC5-SMC6 complex component [Source:HGNC Symbol;Acc:HGNC:29897] |
| Ensembl ID | ENSG00000169189 |
| Bio databases IDs | |
| Aliases | NSE1 homolog, SMC5-SMC6 complex component |
| Synonyms | 2510027N19Rik, NSE1, NSE1 homolog, SMC5-SMC6 complex component, RGD1307760 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NSMCE1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- protein kinase C conserved region 1 (C1 domain) superfamily
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Nse1 non-SMC component of SMC5-6 complex
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allergy
- peripheral arterial disease
- asthma
role in cell
- cell death
- cell survival
- camptothecin sensitivity
- cisplatin sensitivity
- DNA damage response
- methyl methanesulfonate sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- nucleoplasm
- spindle pole
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NSMCE1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein sumoylation
- double-strand break repair via homologous recombination
- response to DNA damage stimulus
- regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- intracellular membrane-bounded organelle
- Smc5-Smc6 complex
- chromosome, centromeric region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding
- protein dimerization activity