Nsmce4a Gene Summary [Mouse]
Predicted to be involved in DNA repair. Predicted to be located in nuclear body. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Orthologous to human NSMCE4A (NSE4 homolog A, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nsmce4a |
| Official Name | NSE4 homolog A, SMC5-SMC6 complex component [Source:MGI Symbol;Acc:MGI:1915122] |
| Ensembl ID | ENSMUSG00000040331 |
| Bio databases IDs | |
| Aliases | NSE4 homolog A, SMC5-SMC6 complex component |
| Synonyms | 2410003A14Rik, C10orf86, FLJ20003, NS4EA, NSE4A, NSE4 homolog A, SMC5-SMC6 complex component, RGD1309025 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nsmce4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Binding domain of Nse4/EID3 to Nse3-MAGE
- protein binding
- Nse4 C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nsmce4a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- protein sumoylation
- double-strand break repair via homologous recombination
- response to DNA damage stimulus
- regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- nuclear body
- Smc5-Smc6 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding