Lancl1 Gene Summary [Mouse]
Enables glutathione transferase activity. Involved in cellular detoxification. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human LANCL1 (LanC like glutathione S-transferase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lancl1 |
| Official Name | LanC (bacterial lantibiotic synthetase component C)-like 1 [Source:MGI Symbol;Acc:MGI:1336997] |
| Ensembl ID | ENSMUSG00000026000 |
| Bio databases IDs | |
| Aliases | LanC (bacterial lantibiotic synthetase component C)-like 1 |
| Synonyms | Gpr69, GPR69A, LanC (bacterial lantibiotic synthetase component C)-like 1, LanC like glutathione S-transferase 1, p40 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lancl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- zinc ion binding
- Lanthionine synthetase C-like protein
- glutathione transferase
- Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
- enzyme
- protein binding
- low-density lipoprotein receptor binding
- SH3-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- contracture
- neurodegeneration
- oligozoospermia
- asthenozoospermia
role in cell
- activation in
- apoptosis
- proliferation
- number
- damage
- binding in
- function
- abnormal morphology
- excitotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- Nucleus
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lancl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- G-protein coupled receptor signaling pathway
- peptide modification
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- zinc ion binding
- low-density lipoprotein particle receptor binding
- protein binding
- glutathione binding
- glutathione transferase activity
- SH3 domain binding