Pycard Gene Summary [Mouse]
Enables identical protein binding activity and protein dimerization activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of cytokine production; and regulation of defense response. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; positive regulation of macrophage cytokine production; and regulation of autophagy. Located in cytosol; extracellular region; and nucleus. Part of NLRP6 inflammasome complex. Is expressed in several structures, including alimentary system; brain; heart; hemolymphoid system gland; and urinary system. Orthologous to human PYCARD (PYD and CARD domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pycard |
| Official Name | PYD and CARD domain containing [Source:MGI Symbol;Acc:MGI:1931465] |
| Ensembl ID | ENSMUSG00000030793 |
| Bio databases IDs | |
| Aliases | PYD and CARD domain containing |
| Synonyms | 9130417A21Rik, Asc, CARD5, masc, PYD and CARD domain containing, TMS-1, TNS1 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pycard often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- PAAD/DAPIN/Pyrin domain
- protease binding
- tropomyosin binding
- enzyme binding
- protein domain specific binding
- protein binding
- receptor binding
- identical protein binding
- Caspase recruitment domain
- interleukin-6 receptor binding
- protein homodimerization
- ion channel binding
- apoptotic protease activator
- myosin I binding
- Death Domain Superfamily of protein-protein interaction domains
Pathways
Biological processes and signaling networks where the Pycard gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- delayed hypersensitive reaction
- ulcerative colitis
- collagen-induced arthritis
- pneumococcal meningitis
- autoinflammatory disorder
- insulin resistance
- endotoxin shock response
- experimental autoimmune encephalomyelitis
role in cell
- phosphorylation in
- activation in
- apoptosis
- expression in
- proliferation
- cell death
- activation
- generation in
- number
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- Mitochondria
- cytosol
- Golgi membrane
- nucleoplasm
- nucleoli
- perikaryon