Nlrp1b Gene Summary [Mouse]
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and cysteine-type endopeptidase activator activity. Acts upstream of or within protein catabolic process and pyroptotic inflammatory response. Predicted to be located in nucleoplasm. Predicted to be part of NLRP1 inflammasome complex and NLRP3 inflammasome complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nlrp1b |
| Official Name | NLR family, pyrin domain containing 1B [Source:MGI Symbol;Acc:MGI:3582959] |
| Ensembl ID | ENSMUSG00000070390 |
| Bio databases IDs | |
| Aliases | NLR family, pyrin domain containing 1B |
| Synonyms | AABR07029890.1, LOC100504795, LOC115486391, LOC115489409, LOC115489413, LOC687768, LT629147.6, LT629150.1, LT629150.3, LT629153.5, Nalp1b, NLR family, pyrin domain containing 1B |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nlrp1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLRC4 helical domain HD2
- NOD2 winged helix domain
- AAA ATPase domain
- signaling receptor activity
- peptidase
- protein binding activity, bridging
- ATP binding
- Leucine rich repeat
- enzyme binding
- protein domain specific binding
- enzyme regulator activity
- NACHT domain
- protease activator
- ATPase
- Caspase recruitment domain
- Function to find
- endopeptidase
- double-stranded DNA binding
- Leucine rich repeat, ribonuclease inhibitor type
- double-stranded RNA binding
- Death Domain Superfamily of protein-protein interaction domains
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Nlrp1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cerebral hemorrhage
role in cell
- cell death
- apoptosis
- function
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm