Flvcr1 Gene Summary [Mouse]
Predicted to enable heme binding activity; heme transmembrane transporter activity; and organic cation transmembrane transporter activity. Acts upstream of or within several processes, including chordate embryonic development; embryonic digit morphogenesis; and spleen development. Located in mitochondrial membrane and plasma membrane. Is expressed in several structures, including duodenum; ectoplacental cone; immune system; placenta; and yolk sac. Used to study Diamond-Blackfan anemia. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with microcephaly, absent speech, and hypotonia. Orthologous to human FLVCR1 (FLVCR choline and heme transporter 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Flvcr1 |
| Official Name | feline leukemia virus subgroup C cellular receptor 1 [Source:MGI Symbol;Acc:MGI:2444881] |
| Ensembl ID | ENSMUSG00000066595 |
| Bio databases IDs | |
| Aliases | feline leukemia virus subgroup C cellular receptor 1 |
| Synonyms | 9630055N22Rik, AXPC1, feline leukaemia virus subgroup C cellular receptor 1, feline leukemia virus subgroup C cellular receptor 1, FLVCR, FLVCR choline and heme transporter 1, LOC100909719, MFSD7B, NEDMISH, PCA, PCARP, RETSNS, SLC49A1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Flvcr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amine/polyamine transporter
- organic cation transporter
- organic alcohol transporter
- Major Facilitator Superfamily
- choline transporter
- protein binding
- heme transporter
- transporter
Pathways
Biological processes and signaling networks where the Flvcr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- retinal dystrophy
- retinitis pigmentosa
- degenerative disc disease
- hereditary disorder
- hepatocellular carcinoma
- liver cancer
- fundus flavimaculatus
- Jeune syndrome
- posterior column ataxia with retinitis pigmentosa
role in cell
- expression in
- production in
- glycolysis in
- quantity
- proliferation
- differentiation
- mass
- tubulation
- ferroptosis
- tubulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Flvcr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- transmembrane transport
- heme biosynthetic process
- spleen development
- regulation of organ growth
- head morphogenesis
- embryonic skeletal system morphogenesis
- erythrocyte maturation
- embryonic digit morphogenesis
- cellular iron ion homeostasis
- erythrocyte differentiation
- blood vessel development
- mitochondrial transport
- heme export
- in utero embryonic development
- heme transport
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- membrane
- mitochondrial inner membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- heme transporter activity
- heme binding