Rrm1 Gene Summary [Mouse]
Enables disordered domain specific binding activity; purine nucleotide binding activity; and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in several processes, including nucleoside phosphate metabolic process; positive regulation of G0 to G1 transition; and protein heterotetramerization. Part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in chronic progressive external ophthalmoplegia. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rrm1 |
| Official Name | ribonucleotide reductase M1 [Source:MGI Symbol;Acc:MGI:98180] |
| Ensembl ID | ENSMUSG00000030978 |
| Bio databases IDs | |
| Aliases | ribonucleotide reductase M1 |
| Synonyms | LOC100361270, PEOB6, R1, RIBONUCLEOTIDE REDUCTASE, ribonucleotide reductase catalytic subunit M1, RIBONUCLEOTIDE REDUCTASE M1, RIR1, RnrM1, RNR subunit R1, RR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rrm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribonucleotide reductase and Pyruvate formate lyase
- Ribonucleotide reductase, barrel domain
- ribonucleoside-diphosphate reductase, alpha subunit
- Ribonucleotide reductase, all-alpha domain
- ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent
- protein domain specific binding
- enzyme
- protein binding
- purine nucleotide binding
- identical protein binding
- CH2 group:disulfide oxidoreductase
- ATP cone domain
- ribonucleoside-diphosphate reductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- invasive breast cancer
- metastatic invasive breast cancer
- metastatic breast cancer
- advanced breast cancer
- treatment-related acute myeloid leukemia
- acute myeloid leukemia
- HER2-positive breast cancer
- myeloproliferative disorder
- neoplasia
role in cell
- expression in
- cell viability
- apoptosis
- survival
- synthesis in
- proliferation
- phosphorylation in
- migration
- cell cycle progression
- progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- basal bodies
- centrosome
- Mitochondria
- cytosol
- nuclear envelope
- cellular protrusions
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rrm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribonucleoside diphosphate metabolic process
- DNA repair
- male gonad development
- positive regulation of G1/S transition of mitotic cell cycle
- retina development in camera-type eye
- 2'-deoxyribonucleotide biosynthetic process
- cell proliferation in forebrain
- deoxyribonucleotide biosynthetic process
- mitochondrial DNA replication
- DNA synthesis involved in DNA repair
- protein heterotetramerization
- pyrimidine base metabolic process
- positive regulation of G0 to G1 transition
- response to ionizing radiation
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- mitochondrion
- cytosol
- neuronal cell body
- cell projection
- ribonucleoside-diphosphate reductase complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor