Denn2b Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within positive regulation of ERK1 and ERK2 cascade. Predicted to be located in cell cortex; plasma membrane; and recycling endosome. Is expressed in several structures, including brain; future brain; head mesenchyme; heart; and primary palate. Orthologous to human DENND2B (DENN domain containing 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Denn2b |
| Official Name | DENN domain containing 2B [Source:MGI Symbol;Acc:MGI:108517] |
| Ensembl ID | ENSMUSG00000031024 |
| Bio databases IDs | |
| Aliases | DENN domain containing 2B |
| Synonyms | 2010004M01Rik, 2610305K15Rik, Denn2b, DENN domain containing 2B, HTS1, LOC102554209, ST5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Denn2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DENN (AEX-3) domain
- guanyl-nucleotide exchange factor
- dDENN domain
- enzyme
- protein binding
- proline rich domain
- uDENN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myocardial infarction
- Parkinson disease
- leiomyosarcoma
- soft tissue sarcoma cancer
- coronary artery disease
- colorectal cancer
- hypospadia
- schizophrenia
role in cell
- morphology
- transformation
- contact growth inhibition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Denn2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of ERK1 and ERK2 cascade
Cellular Component
Where in the cell the gene product is active
- cell cortex
- recycling endosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity