Dock11 Gene Summary [Mouse]
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including marginal zone B cell differentiation; positive regulation of GTPase activity; and positive regulation of filopodium assembly. Is expressed in brain; female reproductive system; gut; skin; and spleen. Orthologous to human DOCK11 (dedicator of cytokinesis 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dock11 |
| Official Name | dedicator of cytokinesis 11 [Source:MGI Symbol;Acc:MGI:1923224] |
| Ensembl ID | ENSMUSG00000031093 |
| Bio databases IDs | |
| Aliases | dedicator of cytokinesis 11 |
| Synonyms | 5033414A21RIK, 8030476J24, ACG, ADMIDX, bB128O4.1, dedicator of cytokinesis 11, sph238, ZIZ2, Zizimin2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dock11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DHR-2, Lobe B
- C2 domain in Dock180 and Zizimin proteins
- Dedicator of cytokinesis C/D, N terminal
- Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
- DHR-2, Lobe A
- guanyl-nucleotide exchange factor
- PH domain
- enzyme binding
- protein binding
- Pleckstrin homology-like domain
- C2 domain
- DHR-2, Lobe C
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked multisystem autoinflammatory disease with immune dysregulation
- cleft lip
regulates
- GTPase
role in cell
- migration
- chemotaxis
- number
- differentiation
- homeostasis
- maintenance in
- assembly
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dock11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- marginal zone B cell differentiation
- small GTPase mediated signal transduction
- positive regulation of filopodium assembly
- B cell homeostasis
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding