Itm2a Gene Summary [Mouse]
Predicted to enable amyloid-beta binding activity. Acts upstream of or within plasma cell differentiation. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in several structures, including 1st branchial arch mandibular component; alimentary system; eye; vascular element; and vault of skull. Orthologous to human ITM2A (integral membrane protein 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itm2a |
| Official Name | integral membrane protein 2A [Source:MGI Symbol;Acc:MGI:107706] |
| Ensembl ID | ENSMUSG00000031239 |
| Bio databases IDs | |
| Aliases | integral membrane protein 2A |
| Synonyms | BRI1, BRICD2A, E25, E25A, integral membrane protein 2A, Itm2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itm2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- BRICHOS domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine serous papillary cancer
- endometriosis
regulates
- CD8
- Immunoglobulin
role in cell
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- vesicles
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itm2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- plasma cell differentiation
- negative regulation of amyloid precursor protein biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-amyloid binding