Sit1 Gene Summary [Mouse]
Predicted to enable kinase binding activity. Predicted to be involved in regulation of T cell activation. Predicted to be active in plasma membrane. Orthologous to human SIT1 (signaling threshold regulating transmembrane adaptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sit1 |
| Official Name | suppression inducing transmembrane adaptor 1 [Source:MGI Symbol;Acc:MGI:1889342] |
| Ensembl ID | ENSMUSG00000028460 |
| Bio databases IDs | |
| Aliases | suppression inducing transmembrane adaptor 1 |
| Synonyms | signaling threshold regulating transmembrane adaptor 1, SIT, SIT-R, suppression inducing transmembrane adaptor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sit1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase binding
- SH2-domain binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- hypoplasia
- hyperplasia
- diabetic nephropathy
role in cell
- expression in
- activation in
- differentiation
- activation
- proliferation
- quantity
- abnormal quantity
- number
- development
- positive selection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sit1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- adaptive immune response
- regulation of T cell activation
- T cell homeostasis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH2 domain binding
- kinase binding