Tnmd Gene Summary [Mouse]
Acts upstream of or within endothelial cell morphogenesis; negative regulation of angiogenesis; and negative regulation of endothelial cell proliferation. Predicted to be located in membrane and nuclear envelope. Is expressed in several structures, including brain; connective tissue; limb; musculoskeletal system; and spinal cord. Orthologous to human TNMD (tenomodulin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnmd |
| Official Name | tenomodulin [Source:MGI Symbol;Acc:MGI:1929885] |
| Ensembl ID | ENSMUSG00000031250 |
| Bio databases IDs | |
| Aliases | tenomodulin |
| Synonyms | 1110017I01Rik, BRICD4, CHM1L, hChM1L, hTeM, TEM, tendin, tenomodulin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnmd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- BRICHOS domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- rhabdomyosarcoma
- soft tissue sarcoma cancer
- hepatoblastoma
- liver cancer
regulates
- Collagen type I (complex)
- collagen fiber
role in cell
- adhesion
- proliferation
- density
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoskeleton
- cellular membrane
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnmd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- endothelial cell morphogenesis
- negative regulation of endothelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding