Onecut2 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including negative regulation of transforming growth factor beta receptor signaling pathway; peripheral nervous system neuron development; and positive regulation of mesenchymal stem cell migration. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; future brain; genitourinary system; gut; and retina. Orthologous to human ONECUT2 (one cut homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Onecut2 |
| Official Name | one cut domain, family member 2 [Source:MGI Symbol;Acc:MGI:1891408] |
| Ensembl ID | ENSMUSG00000045991 |
| Bio databases IDs | |
| Aliases | one cut domain, family member 2 |
| Synonyms | C730009D12, LOC112267870, OC-2, one cut domain, family member 2, one cut homeobox 2, RGD1564677 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Onecut2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- CUT domain
- nucleic acid binding
- double-stranded DNA binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- neoplasia
- epithelial cancer
- lung squamous cell carcinoma
- prostate cancer
- diabetes mellitus
- squamous cell lung cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- urothelial bladder carcinoma
role in cell
- expression in
- apoptosis
- proliferation
- growth
- migration
- number
- assembly
- colony formation
- development
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- actin cytoskeleton
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Onecut2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- transforming growth factor beta receptor signaling pathway
- epithelial cell development
- positive regulation of transcription from RNA polymerase II promoter
- peripheral nervous system neuron development
- organ morphogenesis
- regulation of transcription from RNA polymerase II promoter
- regulation of cell-matrix adhesion
- liver development
- cell fate commitment
- endocrine pancreas development
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- actin cytoskeleton
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity