Chrdl1 Gene Summary [Mouse]
Enables BMP binding activity and transforming growth factor beta binding activity. Involved in several processes, including BMP signaling pathway; excitatory chemical synaptic transmission; and synapse organization. Is active in extracellular region. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; neural ectoderm; and skeletal system. Human ortholog(s) of this gene implicated in megalocornea. Orthologous to human CHRDL1 (chordin like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrdl1 |
| Official Name | chordin-like 1 [Source:MGI Symbol;Acc:MGI:1933172] |
| Ensembl ID | ENSMUSG00000031283 |
| Bio databases IDs | |
| Aliases | chordin-like 1 |
| Synonyms | BB139951, CHL, CHL1, CHORDIN-LIKE, chordin-like 1, dA141H5.1, Kjr, MGC1, MGCN, Neuralin, Neurogenesin-1, Ng1, NRLN1, VOPT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chrdl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- von Willebrand factor type C domain
- cytokine binding
- Chordin-like protein 1/2 C-terminal
- TGFbeta binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- non-small cell lung cancer
- small cell lung cancer
- megalocornea
- coronary artery disease
- X-linked megalocornea type 1
- uterine serous papillary cancer
- thyroid cancer
role in cell
- expression in
- senescence
- differentiation
- maturation
- plasticity
- fate determination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chrdl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering
- eye development
- ossification
- synapse maturation
- BMP signaling pathway
- regulation of synaptic plasticity
- cell differentiation
- embryonic axis specification
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- synapse
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transforming growth factor beta binding
- BMP binding