CHRDL1 Gene Summary [Human]
This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | CHRDL1 |
| Official Name | chordin like 1 [Source:HGNC Symbol;Acc:HGNC:29861] |
| Ensembl ID | ENSG00000101938 |
| Bio databases IDs | |
| Aliases | chordin like 1 |
| Synonyms | BB139951, CHL, CHL1, CHORDIN-LIKE, chordin-like 1, dA141H5.1, Kjr, MGC1, MGCN, Neuralin, Neurogenesin-1, Ng1, NRLN1, VOPT |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHRDL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- von Willebrand factor type C domain
- cytokine binding
- Chordin-like protein 1/2 C-terminal
- TGFbeta binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- non-small cell lung cancer
- small cell lung cancer
- megalocornea
- coronary artery disease
- X-linked megalocornea type 1
- uterine serous papillary cancer
- thyroid cancer
role in cell
- expression in
- senescence
- differentiation
- maturation
- plasticity
- fate determination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHRDL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering
- eye development
- ossification
- synapse maturation
- BMP signaling pathway
- regulation of synaptic plasticity
- cell differentiation
- embryonic axis specification
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- synapse
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transforming growth factor beta binding
- BMP binding