Cd27 Gene Summary [Mouse]
Enables transmembrane signaling receptor activity. Involved in CD27 signaling pathway; negative regulation of apoptotic process; and positive regulation of JNK cascade. Acts upstream of or within negative regulation of T cell apoptotic process. Located in external side of plasma membrane. Is active in plasma membrane. Is expressed in several structures, including femur; hemolymphoid system; intestine; pituitary gland; and reproductive system. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 2. Orthologous to human CD27 (CD27 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd27 |
| Official Name | CD27 antigen [Source:MGI Symbol;Acc:MGI:88326] |
| Ensembl ID | ENSMUSG00000030336 |
| Bio databases IDs | |
| Aliases | CD27 antigen |
| Synonyms | CD27 antigen, CD27 molecule, LOC100048672, S152, S152. LPFS2, T14, TNFRSF7, Tp55 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- traf2 binding domain
- extracellular domain
- costimulatory domain
- cytoplasmic domain
- caspase inhibitor activity
- intracellular domain
- protein binding
- cytosolic tail domain
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Cd27 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- multiple sclerosis
- neoplasia
- epithelial neoplasia
- epithelial cancer
- liver cancer
- lung adenocarcinoma formation
- lymphatic neoplasia
- lymphoproliferative syndrome type 2
- tuberculosis
role in cell
- expression in
- number
- quantity
- function
- differentiation
- activation
- proliferation
- survival
- apoptosis
- clonal expansion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to ethanol
- negative regulation of T cell apoptotic process
- negative regulation of apoptotic process
- positive regulation of JNK cascade
- positive regulation of T cell differentiation
- immunoglobulin mediated immune response
- extrinsic apoptotic signaling pathway
- cell surface receptor signaling pathway
- positive regulation of B cell differentiation
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process