ATP11A Gene Summary [Human]
The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. [provided by RefSeq, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ATP11A |
| Official Name | ATPase phospholipid transporting 11A [Source:HGNC Symbol;Acc:HGNC:13552] |
| Ensembl ID | ENSG00000068650 |
| Bio databases IDs | |
| Aliases | ATPase phospholipid transporting 11A, potential phospholipid-transporting ATPase IH, phospholipid-translocating ATPase |
| Synonyms | 4930558F19Rik, ATPase, class 1, member h, ATPase, class VI, type 11A, ATPase phospholipid transporting 11A, Atpc1h, ATPIH, ATPIS, ATPVIH, AUNA2, DFNA84, HLD24, Ih, UA20 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATP11A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- R3H
- phospholipid transporter
- Phospholipid-translocating ATPase N-terminal
- protein binding
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- Phospholipid-translocating P-type ATPase C-terminal
- lipid transporter
- aminophospholipid transporter
- phospholipid-translocating P-type ATPase, flippase
- Cation transport ATPase (P-type)
- Haloacid Dehalogenase-like Hydrolases
- transporter
- haloacid dehalogenase-like hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- skin cancer
- squamous cell cancer
- epithelial cancer
- skin neoplasia
- interstitial lung disease
- COVID-19
- critical COVID-19
- autosomal dominant deafness type 84
- sunburn
- diabetic nephropathy
regulates
- Shiga toxin 2
- phosphatidylserine
- phosphatidylethanolamine
role in cell
- differentiation
- exposure in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- tertiary granule membrane
- specific granule membrane
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATP11A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of membrane lipid distribution
- phospholipid translocation
- in utero embryonic development
- positive regulation of myotube differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- early endosome
- intracellular membrane-bounded organelle
- membrane
- recycling endosome
- endoplasmic reticulum
- Golgi apparatus
- tertiary granule membrane
- lysosomal membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- magnesium ion binding
- ATP binding
- protein binding