Rps12 Gene Summary [Mouse]
Predicted to be a structural constituent of ribosome. Predicted to be involved in maintenance of translational fidelity and ribosomal small subunit biogenesis. Is active in synapse. Orthologous to human RPS12 (ribosomal protein S12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Rps12 |
| Official Name | ribosomal protein S12 [Source:MGI Symbol;Acc:MGI:98105] |
| Ensembl ID | ENSMUSG00000061983 |
| Bio databases IDs | |
| Aliases | ribosomal protein S12 |
| Synonyms | eS12, Ribosomal protein s12, RS12, S12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rps12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
- protein binding
Pathways
Biological processes and signaling networks where the Rps12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- infection
- hepatic encephalopathy
- keratitis
- chronic anterior uveitis
- palpebral and bulbar conjunctivitis
- ophthalmia
- Alzheimer disease
- corneal injury
- bulbar conjunctivitis
role in cell
- cell death
- translation in
- nuclear export in
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- pre-ribosome
- ribosome
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoplasm
- nucleoli
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rps12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- ribosomal small subunit biogenesis
- positive regulation of canonical Wnt receptor signaling pathway
- translation
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- cytosolic ribosome
- cytosolic small ribosomal subunit
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- Golgi apparatus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- structural constituent of ribosome