Ap3m2 Gene Summary [Mouse]

Involved in anterograde synaptic vesicle transport and synaptic vesicle endocytosis. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in central nervous system; ganglia; and sensory organ. Orthologous to human AP3M2 (adaptor related protein complex 3 subunit mu 2). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Ap3m2
Official Name
adaptor-related protein complex 3, mu 2 subunit [Source:MGI Symbol;Acc:MGI:1929214]
Ensembl ID
ENSMUSG00000031539
Bio databases IDs NCBI: 64933 Ensembl: ENSMUSG00000031539
Aliases adaptor-related protein complex 3, mu 2 subunit
Synonyms 5830445E16Rik, adaptor-related protein complex 3, mu 2 subunit, adaptor related protein complex 3 subunit mu 2, AP-3B, Ap3m3b, AP47B, CLA20, P47B, p47MU3B
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ap3m2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • AP_MHD_Cterm
  • Adaptor complexes medium subunit family
  • protein binding
  • Longin-like domains
  • transporter

Pathways

Biological processes and signaling networks where the Ap3m2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • seizures
  • epileptic seizure
  • kindling
  • breast cancer
  • colon cancer
  • nonconvulsive seizure
  • rectal adenocarcinoma
  • colorectal carcinomagenesis
  • rectum cancer
  • colon adenocarcinoma
regulated by
regulates
role in cell
  • long-term potentiation
  • production
  • abnormal morphology
  • morphology
  • endocytosis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • glutaminergic synapse
  • Plasma Membrane
  • Golgi Apparatus
  • synaptic vesicles
  • synapse

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ap3m2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • anterograde axon cargo transport
  • synaptic vesicle coating
  • intracellular transport
  • intracellular protein transport
  • endocytosis
  • cargo loading into clathrin-coated vesicle, AP-3-mediated
  • anterograde synaptic vesicle transport

Cellular Component

Where in the cell the gene product is active
  • cytoplasmic vesicle membrane
  • early endosome
  • AP-type membrane coat adaptor complex
  • cytoplasmic vesicle
  • clathrin adaptor complex
  • Golgi apparatus
  • AP-3 adaptor complex

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.