Ap3m2 Gene Summary [Rat]
Predicted to be involved in anterograde synaptic vesicle transport and synaptic vesicle endocytosis. Is active in synaptic vesicle. Orthologous to human AP3M2 (adaptor related protein complex 3 subunit mu 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ap3m2 |
| Official Name | adaptor related protein complex 3 subunit mu 2 [Source:RGD Symbol;Acc:70969] |
| Ensembl ID | ENSRNOG00000018650 |
| Bio databases IDs | |
| Aliases | adaptor related protein complex 3 subunit mu 2 |
| Synonyms | 5830445E16Rik, adaptor-related protein complex 3, mu 2 subunit, adaptor related protein complex 3 subunit mu 2, AP-3B, Ap3m3b, AP47B, CLA20, P47B, p47MU3B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ap3m2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AP_MHD_Cterm
- Adaptor complexes medium subunit family
- protein binding
- Longin-like domains
- transporter
Pathways
Biological processes and signaling networks where the Ap3m2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- epileptic seizure
- kindling
- breast cancer
- colon cancer
- nonconvulsive seizure
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- colon adenocarcinoma
regulates
- GABA
- SLC32A1
- neurotransmitter
role in cell
- long-term potentiation
- production
- abnormal morphology
- morphology
- endocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- Plasma Membrane
- Golgi Apparatus
- synaptic vesicles
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ap3m2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anterograde axon cargo transport
- synaptic vesicle coating
- intracellular transport
- intracellular protein transport
- endocytosis
- cargo loading into clathrin-coated vesicle, AP-3-mediated
- anterograde synaptic vesicle transport
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- early endosome
- AP-type membrane coat adaptor complex
- cytoplasmic vesicle
- clathrin adaptor complex
- Golgi apparatus
- AP-3 adaptor complex