Gins4 Gene Summary [Mouse]
Acts upstream of or within inner cell mass cell proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including 4-cell stage embryo; bone marrow; brain; genitourinary system; and inner cell mass. Orthologous to human GINS4 (GINS complex subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gins4 |
| Official Name | GINS complex subunit 4 (Sld5 homolog) [Source:MGI Symbol;Acc:MGI:1923847] |
| Ensembl ID | ENSMUSG00000031546 |
| Bio databases IDs | |
| Aliases | GINS complex subunit 4 (Sld5 homolog) |
| Synonyms | 2810037C03Rik, 4933405K01Rik, GINS complex subunit 4, RGD1307397, SLD5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gins4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha-helical domain of GINS complex proteins (Sld5, Psf1, Psf2 and Psf3)
- DNA replication complex GINS protein SLD5 C-terminus
- GINS_B
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gins4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner cell mass cell proliferation
- double-strand break repair via break-induced replication
- DNA unwinding involved in replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- CMG complex
- cytoplasm
- GINS complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding