Cdc45 Gene Summary [Mouse]
Predicted to enable DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in DNA replication initiation; double-strand break repair via break-induced replication; and mitotic DNA replication preinitiation complex assembly. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of CMG complex. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and notochord. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdc45 |
| Official Name | cell division cycle 45 [Source:MGI Symbol;Acc:MGI:1338073] |
| Ensembl ID | ENSMUSG00000000028 |
| Bio databases IDs | |
| Aliases | cell division cycle 45 |
| Synonyms | Cdc45i, CDC45L, CDC45L2, cell division cycle 45, LOC287961, MGORS7, PORC-PI-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdc45 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CDC45-like protein
- protein binding
Pathways
Biological processes and signaling networks where the Cdc45 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Meier-Gorlin syndrome type 7
- plexiform neurofibroma
- HER2 negative hormone receptor negative breast cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- dementia
- Dukes stage C colorectal cancer
- global developmental delay with intellectual disability
- nonsyndromic cleft lip and palate
regulates
role in cell
- apoptosis
- formation
- formation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- basal bodies
- centrosome
- nucleoplasm
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdc45 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- DNA replication checkpoint
- double-strand break repair via break-induced replication
- DNA unwinding involved in replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- CMG complex
- cilium basal body
- DNA replication preinitiation complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA replication origin binding
- protein binding
- chromatin binding
- single-stranded DNA binding