Sap30 Gene Summary [Mouse]
Predicted to enable transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including branchial arch; cerebral cortex; early embryo; limb bud; and sensory organ. Orthologous to human SAP30 (Sin3A associated protein 30). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sap30 |
| Official Name | sin3 associated polypeptide [Source:MGI Symbol;Acc:MGI:1929129] |
| Ensembl ID | ENSMUSG00000031609 |
| Bio databases IDs | |
| Aliases | sin3 associated polypeptide |
| Synonyms | Sin3A associated protein 30, sin3 associated polypeptide |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sap30 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- silencing domain
- transcription regulator
- SAP30 zinc-finger
- amphipathic helix
- transcription co-repressor
- histone deacetylase binding domain
- protein binding
- Sin3 binding region of histone deacetylase complex subunit SAP30
Pathways
Biological processes and signaling networks where the Sap30 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- metastasis
- chromosomal instability
- HER2-positive breast cancer
- estrogen receptor positive breast cancer
- HER2 negative hormone receptor negative breast cancer
- sarcoidosis
role in cell
- expression in
- differentiation
- repression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sap30 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- skeletal muscle cell differentiation
- modulation by host of symbiont transcription
- regulation of transcription, DNA-dependent
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- histone deacetylase complex
- nucleoplasm
- Sin3-type complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- transcription cofactor activity
- protein binding
- transcription corepressor activity
- metal ion binding