Brms1 Gene Summary [Mouse]
Predicted to enable NF-kappaB binding activity and histone deacetylase binding activity. Predicted to be involved in positive regulation of anoikis; positive regulation of protein deacetylation; and regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Predicted to be part of Sin3-type complex. Is expressed in alimentary system; central nervous system; genitourinary system; heart; and respiratory system. Orthologous to human BRMS1 (BRMS1 transcriptional repressor and anoikis regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brms1 |
| Official Name | breast cancer metastasis-suppressor 1 [Source:MGI Symbol;Acc:MGI:2388804] |
| Ensembl ID | ENSMUSG00000080268 |
| Bio databases IDs | |
| Aliases | breast cancer metastasis-suppressor 1 |
| Synonyms | breast cancer metastasis-suppressor 1, BRMS1 transcriptional repressor and anoikis regulator, BRMS1, transcriptional repressor and anoikis regulator, LOC108348098 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brms1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- NF-kappaB binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- chronic fatigue syndrome
- rheumatoid arthritis
- metastasis
- diverticular disease
- advanced cancer
role in cell
- expression in
- apoptosis
- activation in
- growth
- migration
- chemotaxis
- communication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brms1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- positive regulation of protein deacetylation
- negative regulation of NF-kappaB transcription factor activity
- apoptotic process
- regulation of apoptotic process
- positive regulation of anoikis
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- Sin3-type complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- protein binding
- histone deacetylase binding