Cbr4 Gene Summary [Mouse]
Predicted to enable several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Predicted to be involved in fatty acid biosynthetic process; glycoside metabolic process; and protein tetramerization. Located in mitochondrion. Orthologous to human CBR4 (carbonyl reductase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cbr4 |
| Official Name | carbonyl reductase 4 [Source:MGI Symbol;Acc:MGI:2384567] |
| Ensembl ID | ENSMUSG00000031641 |
| Bio databases IDs | |
| Aliases | carbonyl reductase 4 |
| Synonyms | A730083J17Rik, BC009118, carbonyl reductase 4, FLJ14431, LOC100911522, SDR45C1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cbr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- quinone binding
- KR domain
- pteridine reductase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- protein binding
- NADPH2 dehydrogenase (quinone)
- polyketide synthase keto reductase domain
- NADPH binding
- NAD(P)H2 dehydrogenase (quinone)
- sepiapterin reductase
- 3-oxoacyl-(acyl-carrier-protein) reductase
- acetoin reductases
- 3-oxoacyl-[acyl-carrier-protein] reductase
- short chain dehydrogenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cbr4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- daunorubicin metabolic process
- doxorubicin metabolic process
- fatty acid biosynthetic process
- protein heterotetramerization
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
- protein binding
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- quinone binding
- NAD(P)H dehydrogenase (quinone) activity
- NADPH dehydrogenase (quinone) activity
- NADPH binding