CBR4 Gene Summary [Human]
Enables several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Involved in fatty acid biosynthetic process; glycoside metabolic process; and protein tetramerization. Located in mitochondrial matrix. Part of oxidoreductase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | CBR4 |
| Official Name | carbonyl reductase 4 [Source:HGNC Symbol;Acc:HGNC:25891] |
| Ensembl ID | ENSG00000145439 |
| Bio databases IDs | |
| Aliases | carbonyl reductase 4, short chain dehydrogenase/reductase family 45C, member 1 |
| Synonyms | A730083J17Rik, BC009118, carbonyl reductase 4, FLJ14431, LOC100911522, SDR45C1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CBR4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- quinone binding
- KR domain
- pteridine reductase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- protein binding
- NADPH2 dehydrogenase (quinone)
- polyketide synthase keto reductase domain
- NADPH binding
- NAD(P)H2 dehydrogenase (quinone)
- sepiapterin reductase
- 3-oxoacyl-(acyl-carrier-protein) reductase
- acetoin reductases
- 3-oxoacyl-[acyl-carrier-protein] reductase
- short chain dehydrogenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CBR4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- daunorubicin metabolic process
- doxorubicin metabolic process
- fatty acid biosynthetic process
- protein heterotetramerization
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
- protein binding
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- quinone binding
- NAD(P)H dehydrogenase (quinone) activity
- NADPH dehydrogenase (quinone) activity
- NADPH binding